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Down syndrome (DS) causes life-long cognitive impairment which results in significant consequences for the individuals, their families and society leading to a reduced quality of life and social stigma. Despite this heavier social burden and the greater medical needs, there is not an approved therapy for DS-related cognitive impairment yet.

The ICOD project (Improving COgnition in Down syndrome), funded by European Union, aims to address these unmet clinical needs with a first-in-class new pharmacological treatment (AEF0217) specifically designed to address the core cognitive impairment of individuals with DS: working memory. Working memory and memory flexibility play an important role in everyday tasks like following instructions, planning activities or understanding a conversation.

The first ICOD symposium will take place in Troina in 2022 at IRCCS Oasi Research Institute on the occasion of the World Down syndrome Day (March 21st). The symposium will be specifically dedicated to increase the knowledge about innovative therapeutic approaches in the management of cognitive deficits in DS.